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The FXR agonist did not reduce intestinal bacterial overgrowth in mice lacking FXR, which means that the antimicrobial action of the FXR agonist was due to the FXR mediating the activation of bile acid synthesis and not to the biochemical properties of the administered FXR agonist

Research has shown that leukotriene B4, secreted by macrophages in the lungs of PAH rats, induces apoptosis in PAECs and promotes PASMC proliferation [135]

doi: 10.1016/j.cytogfr.2016.09.002 50 MontorfanoIBecerraACerroREcheverraCSezEMoralesMGet al