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J Biol Chem 294(43):1578115794 Weng T, Ko J, Masamha CP, Xia Z, Xiang Y, Chen N-y, Molina JG, Collum S, Mertens TC, Luo F (2019) Cleavage factor 25 deregulation contributes to pulmonary fibrosis through alternative polyadenylation

When NNMT activity is reduced, cells can more efficiently utilize nicotinamide adenine dinucleotide (NAD+), leading to enhanced mitochondrial function and improved metabolic flexibility