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The euchromatic histone-lysine N-methyltransferase 2 (G9a) encoded by the Ehmt2 gene can downregulate the expression of Kcna2 , Oprm1 , Oprk1 , and Oprd1 genes in injury-related DRG neurons in a preclinical mouse model of unilateral L4 SNL [108,109] or unilateral L5/6 SNL of SD rats [110]

consistent with the notion that IL-6 production by non-CAR cells is an indirect effect of CAR T cell activation through a yet to be determined mechanism (35)