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It is released in the body during injury, which is why therapy using it can be progressively utilized both in protecting the function of the respiratory system and in therapy supporting the regeneration of its elements, especially the lungs, because most frequently occurring diseases within this system concern them

The blood brain barrier (BBB) typically restricts access to brain cells by acting as a physical and functional blockade that separates the brain parenchyma from the systemic circulation (see, e.g., Pardridge, et al., J

It is also based on the arginine paradox, discussed above, that despite an intracellular L-arginine concentration much higher than its K m for eNOS activity, high extracellular concentration of L-arginine can still promote NO production