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Lastly, Brachyury expression - often considered a NC marker and required for the differentiation of mesoderm into notochord [3] - was not detected in the human adult NP, which may argue against the hypothesis that both NC and CLCs are derived from the notochord [73]

Slightly different from class I HDACs, Sirt1 ~ 3 have been reported to facilitate a greater degree of delactylation in non-histone proteins compared to histone proteins, which may be attributed to the subcellular localization of Sirt1 and Sirt2 being predominantly in the cytoplasm and mitochondrial matrix, respectively

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