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Evidence gap No published human randomized controlled trial has tested native MOTS-c for any clinical endpoint

"Selective and membrane-permeable small molecule inhibitors of NNMT reverse high fat diet-induced obesity." Biochemical Pharmacology

PCL, poly -caprolactone

Their mechanisms range from angiogenesis and cytoprotection to tight-junction regulation and immune modulation, and the maturity of the evidence varies considerably across the group