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Gut dysbiosis (90, 93, 98), for instance, through the reduction of SCFAs, may affect serotonin and dopamine synthesis (24)

Vitamin E, when administered alone, has modest benefits on blood pressure and blood flow, which are salutary for diabetes and DR patients [186]

Existing studies on chronic irisin administration in metabolic and cardiovascular models have reported sustained benefits without significant toxicity, suggesting that irisin may be a safe therapeutic candidate

Cellular iron metabolism The maintenance of cellular iron homeostasis is achieved through the coordinated regulatory expression of ferritin and other proteins, including Tf