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These microphysiological systems can be linked with in vitro digestion data and omics-level readouts to generate rich training sets for computational models

At supratherapeutic doses of APAP (more than 4 g/day), the sulfation pathway becomes saturated, while glucuronidation and oxidation increase, and a smaller amount is excreted unchanged

Ashour AE, Sayed-Ahmed MM, Abd-Allah AR, Korashy HM, Maayah ZH, Alkhalidi H,

This disease may occur in newborns within 6 months after birth, as characterized by vomiting, developmental delay, serious progressive liver failure, hypotonia, hyperreflexia, irritability, and hypoglycemia