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Stimulated B and T cells can migrate to the blood (IgE and the allergen are distributed throughout the body with bodily fluids), and they are transported back to mucous membranes and the associated lymphatic structures (mainly GALT) where the allergen was first encountered

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Animal models may also help to understand these triggers

doi: 10.1007/s00018-019-03111-7 152 KamT-IHinkleJTDawsonTMDawsonVL