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Moreover, the shortage of glutamine for tumor cells will induce the proliferation and activation of Treg cells, which function as an immunosuppressive effect (Yang et al., 2016)

Control groups received saline injections

28,52,53 Over the past 5 years, a growing body of works have extended this concept to non-malignant inflammatory diseases (eg

El-Husseiny HM, Mady EA, Hamabe L, Abugomaa A, Shimada K, Yoshida T, Tanaka T, Yokoi A, Elbadawy M, Tanaka R (2022) Smart/stimuli-responsive hydrogels: cutting-edge platforms for tissue engineering and other biomedical applications