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However, as it has not yet been officially approved as a drug, it is necessary to fully understand its potential risks before use and use it reasonably under the guidance of a professional doctor

Diabetes 62(7):22152222

Compared with normal lungs, the subpopulation of macrophages that highly express SPP1 and MERTK (SPP1hi) and NTN1 (laminin-like protein netrin-1) increased significantly in IPF lungs

Additionally, these factors may jointly enhance mitochondrial autophagy and stability by counteracting the Warburg effect (a metabolic shift from oxidative phosphorylation to glycolysis in hypoxic solid tumors, leading to increased glucose uptake and decreased oxygen consumption) and thus protect mitochondrial metabolism from carcinogenic transformation (159)