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For final differentiation of nascent T FH into GC T FH , pre-T FH cells require a second costimulatory signal through ICOS (119, 120)

As fibrin accumulates in the site of the trauma, it triggers an inflammatory response involving an overproduction of fibrogenic cytokines and free radicals [5,6,7,8]

A key structural feature is a cyclopentanone ring resembling that in mammalian prostaglandins (surely no coincidence although the biosynthetic mechanisms are very different), but the stereochemistry of the active species has until recently been a cause of confusion