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Some of the characteristic symptoms of this deficiency include: extreme tiredness lack of energy breathlessness feeling faint headaches pale skin noticeable heartbeats (palpitations) loss of appetite and weight loss a decline in your mental abilities (brain fog) irritability depression If youre following a vegan diet and recognise any of the symptoms outlined above (or just wish to prevent them!), a vegan B12 supplement may be required and you have two options available

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A 2021 analytical study developed and validated an LC-MS/MS method to measure 5-amino-1-methylquinolinium in rat plasma and urine