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Third, clinical efforts should include establishing multicenter FRDA biobanks to validate associations between ferroptosis biomarkers (such as ACSL4 and mitochondrial iron content) and clinical measures including SARA ataxia scores and left ventricular ejection fraction, and conducting combination trials of ferroptosis inhibitors with ironsulfur cluster metabolism regulators to evaluate synergistic improvement in neurologic and cardiac function

This type of phosphorylation induces apoptosis and ferroptosis in cells exposed to various stress (Zhang et al., 2022)

Therefore, understanding the molecular mechanisms underlying MQC disruption in EMs is important for identifying therapeutic targets

The dose may need to be adjusted gradually, as your doctor monitors how well the drug is working