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[10,38,39] is thought to have great biological significance in human antioxidant defense system

151 HeQ.LiuJ.LiangJ.LiuX.LiW.LiuZ.et al (2018)

To corroborate the role of a nitrile oxide electrophile in inhibiting GPX4, we attempted to synthesize JKE-1777 analogs containing stable nitrile oxide precursors

Treatment lasted a mean of 134 days, during which consistent increases in IGF-1 were observed at all follow-up intervals, alongside significant rises in testosterone and free testosterone after 90 days