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Nicotinamide mononucleotide, a key NAD + intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice

Both calcium-dependent and calcium-independent forms of PLA 2 are involved in muscle ROS generation

Research (156) has shown that quercetin can inhibit ferroptosis in renal tubular epithelial cells by downregulating the expression of activating transcription factor 3 gene, leading to a significant increase in the expression of SLC7A11 and GPX4

Furthermore, GSTP1-1 has also been shown to bind and inhibit tumor necrosis factor receptor-associated factor 2 (TRAF2), an upstream activator of JNK, thus blocking the MAPK/JNK signaling cascade at multiple levels 29