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Small molecule protein-protein interaction inhibitors as CNS therapeutic agents: current progress and future hurdles

10.1016/j.jpeds.2006.09.040

Cobalt, for instance, is taken up the greatest by legumes such as alfalfa ( Medicago sativa ) and clover ( Trifolium spp.), and much less by grasses

At therapeutic IV concentrations, it modulates NMDA receptors in the brain, which reduces the calcium influx that drives migraine aura and cortical spreading depression