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Elderly patients (65 years) may have increased vulnerability due to polypharmacy, irregular eating patterns, and diminished counterregulatory responses to hypoglycemia

The prescription peptides semaglutide, liraglutide, and tirzepatide are generally intended for people with a body mass index (BMI) of 30 or higher , or a BMI of 27 or higher with weight-related health conditions such as type 2 diabetes, high blood pressure, or sleep apnea (FDA Wegovy prescribing information)

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As a result, researchers theorize that murine models in the Ipamorelin groups could have consumed more food, leading to the observed weight gain