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2018;50:e13012 69

Therefore, targeting the System Xc /GSH/GPX4 axis while minimizing side effects represents a major ongoing challenge and a key direction for future PDAC therapy

LASSS may be more easily accessible to the aforementioned internal disulfide bonds than GSSSG because LASSS (FW: 238.39) is about one-third the size of GSSSG (FW: 644.70)