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The increased levels of ROS is involved in the reduced degradation of tTG by the ubiquitine-proteasome system, thus leading to increased tTG protein levels in susceptible targets as coeliac mucosa

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Extensive research on HD has identified oxidative damage, lipid peroxidation, abnormal glutamate levels, iron accumulation, GSH dysregulation, and reduced GPX activity in both HD patients and animal models (Weiland et al., 2019