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We next further investigated whether the observed bell-shaped profile induced by high concentrations of dimeric macrocycles (3,000 nM) or HGF (30 nM) might be due to off-target inhibition of constitutively activated RTKs, which could potentially transactivate Met phosphorylation

Following incubation, the cells were washed twice with PBS, and then incubated with different constructions of Mxra8 (100 g/mL) for an additional 30 min

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19 , 137 However, they should be used with caution, especially in people with darker skin types, because of the risk of post-inflammatory hyperpigmentation