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Inhibition of the NF-B pathway has been shown to be important in the anticancer activity of a family of unsaturated forms of vitamin E, tocotrienols

10.1016/S0891-5849(96)00550-3

However, one-electron reduction of molecular oxygen (O 2 ) which happens because of electron leakage through respiratory chain complex I and III, will generate highly reactive molecules known as reactive oxygen species (ROS)