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mTORC1 bi-steric treatment of the RP/MRD cell lines combined with either an SWI/SNF inhibitor or an inhibitor of OXPHOS showed a strong synergistic effect, inducing cuproptosis and cell death

(PubMed) McGarry A, McDermott M, Kieburtz K, et al

Cisplatin Chemistry and Biochemistry of a Leading Anticancer Drug

For instance, a study employing mass spectrometry imaging found significant differences in metabolite distribution in the cerebellar cortex, prefrontal cortex, and hippocampus of depression model mice