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Welsh SP

[DOI] [PMC free article] [PubMed] [Google Scholar] Iadecola C, Anrather J

While Huntingtons disease is widely considered to be due to a gain-of-function toxic effect, it has been demonstrated through selective deletion of Htt in striatal projection neurons of mice that these neurons require Htt for motor regulation, synaptic development, cell health, and survival during aging ( Free copper enhances the aggregational toxicity of Htt (Lobato et al., 2024)