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In sum: Uncertain risks plus an unclear benefit equals a trade-off thats just not worth it

10.1002/bit.25721 Biotechnol

3537 min, 30%40% B

As such, instead of being efficiently degraded, these oxidized macromolecules persist within autophagic and endolysosomal compartments, where they undergo further oxidative modification and polymerization, ultimately forming the highly cross-linked aggregates characteristic of lipofuscin [56]