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The largest review of antioxidants for female subfertility, a 2020 Cochrane systematic review covering 63 trials and 7,760 women, rated the evidence for any live-birth benefit as very low certainty (and a 2026 editorial note records that several of its included trials have since been retracted or placed under expression of concern, which does not change its cautious conclusion and, if anything, reinforces it)

doi: 10.3390/ijms19030907 66 MoXShenXMoXYuFTanWDengZet al

Results from a randomised double-blind placebo controlled study showed the initiation of early caffeine did not reduce the age of first successful extubation, rates of BPD, or the duration of need for supplemental oxygen when compared with the placebo group and this trial was halted due to a non-significant trend towards an increased mortality rate in the caffeine group (97)

Symptomatic improvement when vitamin E was added to the treatment regimen was occasionally reported, but data for hepatic WD are mainly anecdotal because no rigorous studies have been conducted