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Description

doi: 10.1016/s0002-9343(01)00792-6

Systems were equilibrated in isothermal-isobaric conditions (NPT) using the Berendsen barostat 51 with a target pressure of 1 atm, the Langevin thermostat 52 with a target temperature of 310 K, along with a low damping factor of 1 ps 1 and an integration time step of 2 fs

The pressure release that causes the sudden leakage of filler from the syringe is often caused by: A loose needle attachment Poor manufacturing tolerances between the needle and syringe Excessive injection pressure Reusing or manipulating prefilled syringes Incompatible needle changes