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Wolf S, Barton D, Kottschade L, Grothey A, Loprinzi C

indicates that disturbances in the gut microbiota may lead to metabolic changes relevant to depressive-like behaviors, highlighting in particular glycerophospholipid metabolism along the gutbrain axis as a mediating factor in this phenomenon [221]

485 These approaches aim to overcome the challenges associated with conventional treatments by introducing genetically engineered immune cells, logic-gated synthetic gene circuits, and oncolytic viruses, all of which offer increased specificity and efficacy in CSC targeting

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