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immune-mediated diseases, such as systemic sclerosis and primary biliary cirrhosis atopic dermatitis, an autoimmune disease chronic spontaneous urticaria, where wheals, angioedema, or both develop on the skin sensitivity to certain drugs, such as antibiotics eosinophilic esophagitis, which affects the gut eosinophilic gastroenteritis and colitis eosinophilic granulomatosis with polyangiitis (EGPA), previously known as Churg-Strauss Syndrome, which combines features of asthma with inflammation of small blood vessels and other tissue damage What happens in eosinophilic diseases

glutathione plays an important role in protecting living cells from toxicity by detoxifying the reactive intermediates via enzymatic conjugation

Biochim et Biophys Acta (BBA) - Bioenergetics

When activated, Nrf2 disassociates from its repressor protein KEAP1 that reacts with oxidative radicals, translocates to the nucleus, binds to antioxidant response element and induces the transcription of defensive genes