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We searched the primary literature in PubMed, Embase and SciELO from inception to June 2025, using the terms diabetes, retinopathy, diabetic retinopathy, proliferative, non-proliferative, macular edema, fibrates, fenofibrate, hypolipidemic drugs, chronic complications, microvascular complications and vascular complications, as well as their combinations and Boolean operators

Its major clinical feature is loss of oedema-free body weight exceeding 5% of body weight during the previous 12 months or less [1]

These data support the rationale that tumors with elevated GST expression are more sensitive to the cytotoxic effects of TLK286

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