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Potent chemoattractant factors such as MCP-1 and IL-8 then induce migration of monocytes into the subendothelial space (33-35)

S2CID 15338188

The time course of the disease can be episodic (2 or more episodes of HE within the span of 6 months or less) or persistent (a pattern of altered behavior that is always present, with no periods of normalcy)