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Mechanistically, USP10 alleviates LPS-induced renal functional damage by activating the SIRT6-dependent Nrf2/HO-1 signaling pathway to reduce the levels of H 2 O 2 and MDA, inhibiting the Bax and cleaved caspase-3 expressions and elevating the Bcl-2 expression

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Furthermore, a large cohort study in Finland revealed the presence of a single-nucleotide polymorphism (SNP), rs12506228, downstream of the MT1 gene in the vast majority of shift workers