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77 , 78 , 79 , 80 The end result of these changes is the production of rigid, non-deformable erythrocytes that are susceptible to stagnation and destruction by reticuloendothelial macrophages in the spleen and liver

For example, the pH profile of the rate law for Reaction 2 will not only depend on the protonation status of the thiol, but that of the oxidant's as well