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Zinc- 2-glycoprotein (ZAG), a novel adipokine, was shown to be inhibited by a high-fat diet and obesity, inflammatory stimuli (TNF ), glucocorticoid receptor antagonists, eicosapentaenoic acid, and 3-adrenoceptor antagonists, whereas glucocorticoids, cancer cachexia, and 3-agonists increase ZAG production [88]