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394 Aside from the direct effects of brain BAs, peripheral BAs provide signals to the CNS indirectly via the TGR5-dependent GLP-1 pathway and FXR-dependent FGF15/19 pathway

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For instance, several migratory stimuli, including platelet-derived growth factor (PDGF) with the corresponding receptor (PDGF-R), lead to the generation of ROS over minutes to hours (Mbong and Anand-Srivastava, 2012

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