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Immediate effects: Some patients report feeling an improvement in energy levels within 24 to 48 hours, though this varies

Pharmacol Rev 43:109142 Nordt SP, Williams SR, Turchen S, Manoguerra A, Smith D, Clark RF (1996) Hypermagnesemia following an acute ingestion of Epsom salt in a patient with normal renal function

If you are considered low risk, it is sensible to have a check-up annually to see if the neuropathy is progressing, check there are no complications, and reinforce the importance of safety checks