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In particular, GSTP1-1 is able to protect the tumor cells from apoptosis signals by inhibiting c-Jun N-terminal kinase (JNK)a member of the MAPK pathwaynon-catalytically, by direct proteinprotein association 25,26

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In further studies, ALA was found to reduce the activity of furin, a precursor protein that promotes IGF-1R maturation, thereby affecting the subsequent maturation process of IGF-1R [76]

Liu F, Sun ZL, Hu P, et al