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Joint disease in haemophilia: pathophysiology, pain and imaging

These findings could mark a major advancement in the treatment of CHB, offering patients a more effective strategy to manage the disease

Species verification PCR amplification was performed using ITS2 forward primer (5-TGTGTCGATGAAGAGCGCAG) and ITS2 reverse primer (5-TGGTTAGTTTCTTTTCCTCCGC), as described previously (Morphew et al ., Reference Morphew, Eccleston, Wilkinson, McGarry, Perally, Prescott, Ward, Williams, Paterson, Raman and Ravikumar2012)

For genotoxic and carcinogenic compounds or compounds for which data presents high uncertainty on their effects and no intake can be defined as safe, the Margin of Exposure (MoE) approach is used, as suggested by EFSA (Barlow et al