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Furthermore, numerous signal transduction proteins (such as receptors and cytokines) also regulate the transcriptional landscape through the epigenome, resulting in the ultimate regulation of the immune response

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JCI Insight 5:123434

It is possible that mutation of the iron-binding histidines changes the tertiary structure of CDO in such a way that it is no longer recognized by an ubiquitin ligase, resulting in the disruption of cysteine-sensitive ubiquitination and degradation