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Even more fascinating, the authors then injected into normal mice one of the molecules that was markedly elevated in the blood when the mice had a leaky guta metabolite known as 4-ethylphenylsulfate (4-EPS)

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To match the peak steady-state concentration, the loading dose can be calculated from equation (13): TARGET CONCENTRATION INTERVENTION: APPLICATION OF PHARMACOKINETICS & PHARMACODYNAMICS TO DOSE INDIVIDUALIZATION The basic principles outlined above can be applied to the interpretation of clinical drug concentration measurements on the basis of three major pharmacokinetic variables: absorption, clearance, and volume of distribution (and the derived variable, half-life)

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