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There is much interest in the use of natural substances in the fight against diabetes.Citrus pectin has been researched in diabetic rats and found to be effective in treating type 2 DM caused by a low dosage of streptozotocin and a high-fat diet

The remarkable exchange of molecules serving as messengers and signals through signalling pathways stands as a pivotal cornerstone in the biological landscape

Acknowledgements The authors thank Ernest Awoonor-Williams and Rainer Wilcken for helpful discussions, Jimmy Kroman for assistance with the conformer generation/QM calculation workflow [73], and Andreas Lingel, Daniel Gosling, and Damien Hubert for their work with the GSH assay