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The effect of skatole was reduced by blocking intrinsic cytochrome P450 activity and indole-3-carbinole, a known skatole metabolite, was a more potent inducer than skatole

Front Pharmacol 12:620741 Hu S, Sun Q, Xu F, Jiang N, Gao J (2023) Age-related hearing loss and its potential drug candidates: a systematic review

doi:10.1038/nri1529

As the increase in lactate dehydrogenase activity is related to tumor hypoxia, this finding is consistent with the fact that elesclomol is more sensitive to tumor cells that depend on mitochondrial respiration (213)