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Intrinsic factor (IF) by parietal cells travels with the protein-bound vitamin B12 to the small intestine, where the higher pH facilitates hydrolysis of R protein to vitamin B12, which allows vitamin B12 to bind with IF

In terms of monitoring, it is advisable to conduct monthly tests for B12, Hcy and MMA during the initial 6 months, followed by tests every 36 months in LCIG patients (Jia et al

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