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Interestingly, growing evidence supports the concept that IEB dysfunction may be key in the initiation and progression of immune activation and that this may eventually contribute to brain-gut axis dysfunction and symptom generation (228, 234)

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[Google Scholar] Bijalwan S, Randhawa GK, Kaur T: A prospective, randomized and open label study to compare efficacy, safety and quality of life impact of topical glutathione (2%) in comparison to topical tranexamic acid (3%) in adult melasma patients