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We performed a 1:1 matching of subjects treated with ALCAR 3 g/day with 45 not treated subjects and separately a 1:1 matching of subjects treated with ALCAR 1.5 g/day with 45 additional not treated subjects

RNA sequencing data from non-malignant brain tissue samples were downloaded from the GTEx portal ( file version: 2017-06-05_v8_brain_cortex, accession date August 26, 2019) 75, 76