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The principal aims were to optimize the operating conditions, to optimize the specific signal for ESAs while decreasing the cross-reactivity to other proteins, to demonstrate that this method could detect all types of ESAs, to determine if the method could be used with urine and blood samples, to compare this new method to the actual accredited methods and finally to put in place and validate a testing procedure that could be transferred to other anti-doping laboratories

Nitric oxide inhibits methionine synthase activity in vivo and disrupts carbon flow through the folate pathway

Autophagy dysfunction, associated with ferroptosis, has been confirmed in AD patients and animal models

doi: 10.1093/hmg/ddq160 52 DanboltN