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Proteasomal processing results in complete proteolysis of the substrate, while deubiquitinating enzymes (DUBs) recycle ubiquitin molecules for subsequent rounds of degradation, ensuring the efficiency and sustainability of the pathway

We switched her to escitalopram instead of stopping medication altogether

Pediatr Neurol, 2005

349 Similarly, mutations in valosin-containing protein (VCP), a multifunctional AAA-ATPase essential for extracting ubiquitinated proteins from cellular structures and directing them toward degradation, cause multisystem proteinopathies that include ALS, FTD, and inclusion body myopathy