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It is important to note that metformin can significantly affect the levels of various metabolites, including those involved in the glucose metabolism, lipid metabolism, tricarboxylic acid cycle (TCA), and urea cycle (t Hart et al., 2018a)

Thus, it has been found that O-methylated derivatives of ()-epicatechin are able to inhibit the peroxynitrite-mediated nitrotyrosine formation [53]

Furthermore, NPs derived from plants and coated with phytochemicals, and other vital bioactive compounds sourced from plant secondary metabolites may find application in treating foot or limb infections in individuals with diabetes (281, 282)