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Rare side effects at very high doses may include skin breakouts or mild GI discomfort, but serious toxicity is not a practical concern for most people

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Considering the pathogenesis of OA, identifying and developing effective strategies to mitigate vascular permeability may be effective for OA prevention and treatment

6 weeks after vaccination, 1.0 10 5 50% tissue culture infectious dose (TCID 50 ) of SARS-CoV-2 was challenged in intranasal and tracheal routes, and 17 of 32 rhesus monkeys inoculated with Ad26-S.PP were completely protected, and no viral RNA was detected in BAL or nasal swabs, indicating that Ad26-S.PP protects the upper and lower respiratory tracts in the NHP model