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ALFA: allele frequency aggregator

METH-induced neurotoxic effects include damage to dopaminergic and serotonergic terminals, neuronal apoptosis, as well as activated astroglia and microglia that lead to a neuroinflammatory response within the brain (Cadet and Krasnova, 2009

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batch-to-batch variation, contamination with pathogens or lead/arsenic, product- product variability users assume is uniform (but can be diverse within a supply chain), herb-drug interactions like modulating CYP enzymes that change the pharmacokinetics of drugs with narrow therapeutic windows all contribute to problems related to reproducibility and safety (195)